Organometallic Compounds
Medchemexpress LLC m-PEG3-CH2CH2COOH | 67319-28-2 | MFCD11041124 | 97.0% | 236.26 g·mol⁻¹ | C10H20O6 | 5 G
m-PEG3-CH2CH2COOH is a methoxy-terminated PEG3 carboxylic acid used as a short, flexible spacer for bioconjugation chemistry. It is employed as a non-cleavable linker in antibody-drug conjugate (ADC) assembly and as a PEG-based linker in PROTAC and other conjugation workflows, providing a terminal carboxylic acid for coupling reactions and improving solubility of conjugates.
- Methoxy-terminated PEG3 spacer providing flexibility.
- Terminal carboxylic acid suitable for amide coupling and esterification.
- Molecular weight 236.26 g·mol⁻¹ for predictable spacer length.
- High purity (approximately 97.0%) suitable for research applications.
- Available in small research-scale quantities and recommended refrigerated storage for stability.
Medchemexpress LLC NH-bis(PEG3-Boc) | 1814901-03-5 | 98.0% | C26H51NO10 | 1 G
NH-bis(PEG3-Boc) is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are compounds designed with two distinct ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other targets a specific protein. This mechanism exploits the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins. This product appears as a colorless to light yellow liquid.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Facilitates selective degradation of target proteins
- Colorless to light yellow liquid
Medchemexpress LLC N-(Boc-PEG3)-N-bis(PEG2-alcohol) | 2055042-60-7 | C25H52N2O11 | 250 MG
N-(Boc-PEG3)-N-bis(PEG2-alcohol) is a PEG-based PROTAC linker used in the synthesis of Proteolysis Targeting Chimeras (PROTACs). PROTACs are designed to leverage the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. This product is intended for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Enables targeted protein degradation via the ubiquitin-proteasome system
- Facilitates connection between an E3 ubiquitin ligase ligand and a target protein ligand
Medchemexpress LLC Fluorescein dilaurate | 7308-90-9 | 97.3% | 100 MG
Fluorescein dilaurate is a colorimetric probe formed by the reaction of adipic acid dihydrazide and fluorescein isothiocyanate. It is intended for research use only and appears as a white to off-white solid.
- Suitable for research applications
Medchemexpress LLC Fmoc-NH-PEG3-CH2CH2COOH | 867062-95-1 | 99.8% | 443.49 g/mol | C24H29NO7 | 10 G
Fmoc-NH-PEG3-CH2CH2COOH is an Fmoc-protected, PEG3-based linker used as a cleavable ADC linker and as a PEG-based PROTAC linker in synthetic and bioconjugation applications.
- Fmoc-protected amino-PEG3 linker suitable for conjugation.
- Used in ADC and PROTAC synthesis applications.
- Molecular formula C24H29NO7 and molecular weight 443.49 g/mol.
- High purity (99.8%) appropriate for research use.
- Available in multiple pack sizes including 10 G.
TARGETMOL CHEMICALS INC PEMETREXED DISODIUM HEMI 500MG
Also available in 50 mg 100 mg 200 mg and bulk. Please contact Fisher for quotes. Pemetrexed disodium hemipenta hydrate (LY-231514 Disodium Hydrate) is a new-type antifolate and antimetabolite for TS DHFR and GARFT. The Ki of Pemetrexed Disodium Hydrate for TS DHFR and GARFT is 1.3 nM 7.2 nM and 65 nM respectively. purity: 99%
Medchemexpress LLC Ph-PEG3 1g
Ph-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]
Medchemexpress LLC Azido-PEG5-alcohol | 86770-68-5 | >97.0% | 263.29 g/mol | C10H21N3O5 | 25 G
Azido-PEG5-alcohol is an azide-terminated polyethylene glycol (PEG) linker containing five ethylene glycol units that is used as a click-chemistry reagent and as a linker in bioconjugation workflows. It participates in copper-catalyzed and strain-promoted azide-alkyne cycloaddition reactions and is supplied for research use only.
- Azide functional group for click chemistry
- Five-unit PEG spacer adds hydrophilicity and flexibility
- Suitable for antibody-drug conjugate and PROTAC linker synthesis
- Characterized by NMR and LC-MS, purity >97.0%
- Available in multiple package sizes, including 25 G
Medchemexpress LLC (S)-1-(4-(Trifluoromethoxy)phenyl)ethanamine | 951247-75-9 | 99.37% | 205.18 | 100 MG
(S)-1-(4-(Trifluoromethoxy)phenyl)ethanamine is a drug intermediate for the synthesis of various active compounds. It is for research use only and not sold to patients.
- Appearance: Solid-liquid mixture
- Color: Colorless to off-white
- Shipping: Room temperature in continental US; may vary elsewhere
- Storage: 4°C, stored under nitrogen. In solvent: -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
eMolecules Ambeed / (S)-5-(Benzyloxy)-2-(13-dioxoisoindolin-2-yl)-5-oxopentanoic acid / 100mg / 525172025 / A286055 / / 88784-33-2 / MFCD13152207 / 367.357 / C20H17NO6
Ambeed / (S)-5-(Benzyloxy)-2-(13-dioxoisoindolin-2-yl)-5-oxopentanoic acid / 100mg / 525172025 / A286055 / / 88784-33-2 / MFCD13152207 / 367.357 / C20H17NO6
eMolecules Ambeed 2-(Dichloromethyl)-4 4 5 5-tetramethyl-1 3 2-dioxaborolane 250mg 787726831 A327457 0 000 83622-41-7 MFCD27976342 210 890 C7H13BCl2O2
Ambeed 2-(Dichloromethyl)-4 4 5 5-tetramethyl-1 3 2-dioxaborolane 250mg 787726831 A327457 0 000 83622-41-7 MFCD27976342 210 890 C7H13BCl2O2
Medchemexpress LLC Dbco-PEG3-VC-Exatecan | 2754384-70-6 | 96.7% | 1331.44 g/mol | C71H79FN10O15 | 10 MG
DBCO-PEG3-VC-Exatecan is a drug-linker conjugate used in antibody-drug conjugate (ADC) research that couples a DBCO-functionalized PEG3 valine-citrulline cleavable linker to the topoisomerase I inhibitor exatecan.
- Provides a cleavable valine-citrulline (VC) linker for intracellular release.
- Includes a DBCO handle for strain-promoted azide-alkyne cycloaddition (click chemistry).
- Incorporates a PEG3 spacer to improve solubility and linker flexibility.
- Delivers exatecan, a DNA topoisomerase I inhibitor payload.
- High purity (~96.7%) and large molecular weight (~1331.44 g/mol).
- Soluble in DMSO at 50 mg/mL with ultrasonic assistance.
- Stored sealed at -20 °C; in solution, stable at -80 °C for 6 months and -20 °C for 1 month.
Medchemexpress LLC Azido-PEG5-acid | 1425973-16-5 | >98.0% | 335.35 g/mol | C13H25N3O7 | 250 MG
Azido-PEG5-acid is an azide-functional, five-unit polyethylene glycol (PEG5) linker used for conjugation chemistry, including PROTAC and antibody-drug conjugate synthesis, and for click-chemistry applications. Supplied for research use only.
- Peg5 linker with azide functionality for click chemistry.
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Compatible with strain-promoted azide-alkyne cycloaddition (SPAAC) using DBCO or BCN reagents.
- Purity ≥98.0%.
- Appearance: colorless to light yellow liquid.
- Storage: pure form stable at -20°C for 3 years and 4°C for 2 years.